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Study procedures Subjects were scheduled for a screening visit within three weeks of initiation of 4-week intermittent fasting at Baylor College of Medicine in the Texas Medical Center Digestive Diseases Center Clinical Research Core E Laboratory

A randomized, double-blind, placebo-controlled trial found that mulberry extract decreased total glucose and insulin rises without significant side effects

However, individuals who eat a vegetarian or vegan may need to plan their diet more carefully to ensure they get enough B12

The rate of new side effects dropped to near zero

The question is not whether the mechanism makes sense but whether clinical trials will confirm the magnitude of benefit suggested by preclinical and early observational data